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It is the welcome “side effect” to many of our patients by taking BrainGlucose at bed time, owing to the CNS feedback system. If without deprivation of glucose in brain or nocturnal hypoglycemia during sleep, one will not feel craving for foods during daytime. Simple as that!
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GLP-1 drugs were originally developed to prevent dangerous nighttime blood sugar dips in diabetics. However, BrainGlucose takes a similar approach, naturally curbing hunger in both Alzheimer's patients and diabetics without side effects or high costs. This is achieved by mimicking a key feedback loop in the brain, essentially telling it you're full. Similarly, taking ChewFull before a meal can naturally reduce your appetite by inducing a feeling of satiety.
JOURNAL ARTICLE
Key questions for the evaluation of anti-amyloid immunotherapies for Alzheimer’s disease Kathy Y Liu, Nicolas Villain, Scott Ayton, Sarah F Ackley, Vincent Planche, Robert Howard, Madhav Thambisetty Brain Communications, Volume 5, Issue 3, 2023, fcad175, https://doi.org/10.1093/braincomms/fcad175 Published: 02 June 2023 "questions over biases due to unblinding and differential drop out, as well as concerns about safety and clinical and cost-effectiveness remain." ...... Comments: Why this publication raised "questions over Biases due to unblinding....."? Do they suspect the "double blind" clinical studies? Because the injection irritation locally and systemic side effects as FDA states “headache, confusion, dizziness, vision changes, nausea and seizure” or “risk of infusion-related reactions, with symptoms such as flu-like symptoms, nausea, vomiting and changes in blood pressure. “ All these will have obvious impacts on the patients (of course without for placebo control since lack of foreign proteins) and affect their end point evaluation psychologically. Everyone knows that Amyloid beta plaque reduction with PET measurement is not neccessary correlated to positive clinical results. So the double blind study control is absolutely critical. Contrary to popular belief, glucose, a simple sugar, doesn't necessarily lead to weight gain. In fact, it can actually curb appetite - the opposite effect of its infamous "evil twin," fructose.
This surprising fact stems from a key difference in how our brains utilize these sugars. The brain relies solely on glucose for energy. When we consume fructose, it doesn't fulfill this crucial need, leaving our brains unsatisfied and triggering cravings for more food. This explains why table sugar, which is half fructose and half glucose (sucrose), isn't as effective at suppressing appetite as pure glucose. Additionally, sucrose requires digestion and processing to break down into its component sugars, further delaying its ability to satiate the brain. This is where ChewFull comes in. Its readily absorbable glucose bypasses digestion and delivers a direct energy boost to the brain, satiating hunger sooner and potentially reducing overall food intake during meals. * PNAS, May 19, 2015, Vol.112, no.29, 6509-6514 Simply because BrainGlucose treats the root cause of AD, while the drugs has nasty side effects.Alzheimer's disease is a progressive brain disorder that causes problems with memory, thinking, and behavior. One of the most common symptoms of Alzheimer's is...
Bruce Willis should try to take zolpidem with BrainGlucose nightly at bedtime(HS), so that he can gradually regain his circadian cycle and improve his brain function. After his cycle stabilized for a while, he should try very slowly to reduce the amount of zolpidem.
What are the differences between IBS (irritable bowel syndrome) and IBD (inflammatory bowel disease)?
IBSshield helps! Not just because researches showed AD is caused by deprivation of glucose in brain (such as 1-31-2017 Temple Univ.), clinically many AD patients also show symptoms of overnight low glucose in brain: typically, nightmares, night sweats, and hallucinations. Especially during middle stage Alzheimer’s while some patients exhibit higher frequency of symptoms (about twice weekly). That period usually does not last very long ranging from a couple of months up to a year. Passing that critical period, those Alzheimer’s patients could advance to severe stage of AD, when patients typically lose their dignity and independence as described in Johns Hopkins Medicine (www.hopkinsmedicine.org). The underlying cause is explained as recurrent severe deprivation of glucose in brain breaks down memory structures and diminish enzyme activities, which in return triggers hormonal rescue mechanism to stimulate liver to generate sudden over flow of glucose into brain. These lack of glucose then causing spike of glucose roller coaster may eventually “kills” the brain, and make higher glucose content in the end stage of AD.
Thus a smooth supply of glucose during late night sleep is very critical if you or your loved ones experience those symptoms, since important REM sleep cycles requires higher level energy supply in brain to support memory function during this period! Many recent years clinical and research results show deprivation of glucose in brain causing early stage Alzheimer’s disease, such as the study published on 1-31-2017 by the researchers in the medical school of Temple University. However, some study results may cause confusions without expertise analysis. For example, Yang and colleagues published an article “Evidence for brain glucose dysregulation in Alzheimer’s disease (Alzheimer’s & Dementia 14, 2018). This study correlated higher glucose level (can be due to end-stage AD) and diminished activity of glycolysis enzyme (checken or egg paradox) found in deceased AD patients. It ignored the clinical symptoms of nightmares, night sweats, and hallucinations that exist in most early and especially mid stage AD patients. Those symptoms are typical of nocturnal hypoglycemia trigged rebound through hormonal rescue mechanism. It also ignored their own data that showed fasting glucose level correlation and failed to relate typical causing facts of Somogyi effect. Their conclusion should have emphasized the importance of early intervention of AD patients with timed supply of glucose at bedtime, instead of puzzling suggestion of higher glucose level causing the disease.
Thus, clinicians and caregivers should concentrate on their own knowledge on symptoms of AD patients, otherwise it can be misled by some studies. Weight loss Mystery #1: Should I drink iced tea or hot tea? Hot tea!!! Yes, iced tea will give your brain the wrong message of preserving extra energy resource and building extra insulation (fat). If someone tells you to drink iced tea to lose weight owing to fewer calories, they are treating you like a piece of wood! A normal human body is full of feedback mechanisms in the central nerve system (CNS). The next time you go to a restaurant, do not drink too much of that free ice water! During pre-refrigerator era, not many people could access to ice besides winter, so you would not see many overweight people in old films or pictures. Mayor Michael Bloomberg’s 2013 “New York City soft drink size limit rule” could be replaced with an “ice limit rule” for less opposition and more effective to control obesity.
Weight Loss Mystery #2: How do I avoid the weight loss roller coaster? Regaining weight after losing it is common and very disappointing! Along with making long-term, sustainable changes to your eating and exercise routines, we recommend: 1). take 0.5 – 2 tabs of ChewFull right before your main meal daily to control your appetite and avoid over-eating; 2). taking 1-2 caplets of BrainGlucose at bedtime. A smooth and steady blood sugar level during the post-midnight period can calm your brain so that you do not crave calories during the day. |
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December 2023
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